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Alpha-lipoic acid is generally considered safe when taken as an oral supplement or used as a topical ointment. The R-form of alpha-lipoic acid is the active, natural form. Acetyl-L-carnitine helps to reduce oxidative stress. Alpha-lipoic acid is a naturally occurring antioxidant our bodies produce, and when taken as recommended there are no negative side-effects. This content does not have an Arabic version. Orthostatic hypotension (postural hypotension), Carpal tunnel symptoms: Role of nonsurgical treatment, Carpal tunnel syndrome surgery: Immediate and long-term results, FREE book offer – Mayo Clinic Health Letter, Diabetic neuropathy Can dietary supplements help, Advertising and sponsorship opportunities, A need to remove (amputate) your toe, foot or lower leg, Metformin (Glumetza, Riomet, others), a drug used to treat type 2 diabetes, Stomach acid-reducing proton pump inhibitors (Prevacid 24 HR, Prilosec OTC, others), Stomach acid-reducing histamine (H-2) blockers (Tagamet HB, Pepcid AC, others), Vegetables, fruits, legumes and whole grains, Lean meats, fish, and poultry without the skin. Vitamin B-12. https://www.niddk.nih.gov/health-information/diabetes/overview/diet-eating-physical-activity. Larger studies are needed. However, many people have no side effects or only have minor side effects. 2. These are not all of the side effects that may occur. Alpha Lipoic Acid (ALA) is an antioxidant and a nutritional supplement which is used by many people since 1950s for different purposes. © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). The S-form occurs when alpha lipoic acid is synthetically manufactured, creating both the S-form and the active R-form. Side effects are uncommon. Acetyl-L-carnitine. 2016; doi:10.11622/smedj.2016027. Research suggests alpha lipoic acid's anti-inflammatory properties may help slow thinning hair.In common male and female pattern balding, chronic inflammation of hair follicles contributes to hair loss.Another factor is the conversion of testosterone to DHT, a compound that can damage hair follicles.Substances that block the enzyme involved in this conversion are currently used to stop hair … doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: All drugs may cause side effects. Mayo Clinic is a nonprofit organization and proceeds from Web advertising help support our mission. Call your doctor for medical However, if you take this supplement when you have a significant thiamin (vitamin B-1) deficiency, alpha-lipoic toxicity might occur. If the label doesn't specify R-ALA, then it more than likely is part S-ALA and not as effective for treatment. Animal studies suggest alpha lipoic acid can also help protect the heart from the toxic side effects of the chemotherapy drug doxorubicin. Some of the dosage forms listed on this page may not apply to the brand name Alpha-Lipoic-Acid-300. National Center for Complementary and Integrative Health. Alpha-lipoic acid is considered possibly safe when taken orally by adults, when applied to the skin, as well as when taken intravenously. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Alpha lipoic acid is beneficial as health supplement for healthy people and also in … Alpha Lipoic Acid https://naturalmedicines.therapeuticresearch.com. In general, alpha lipoic acid (ALA) is considered a safe supplement to take. The researchers stated that the participants who were on ALA did not experience any unfavorable side effects. This content does not have an English version. The Mayo Clinic recommends not using ALA if you are a heavy user of alcohol. Applies to alpha-lipoic acid: oral tablet. Alpha lipoic acid is considered generally safe for adults to consume, but the most common negative reaction from supplementing ALA is a skin rash. What is alpha lipoic acid used for? The biologically active substance acetyl-l-carnitine alpha lipoic acid, which is … A healthy diet is a critical factor in controlling blood sugar, which is key in managing diabetes and preventing or slowing the progression of diabetes complications such as diabetic neuropathy. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. It's most often used to help with diabetic neuropathy, which is a condition where you lose feeling in areas of your body as a complication of diabetes, like numbness, tingling, and burning pains in your legs and feet. Carpal tunnel exercises: Can they relieve symptoms? Alpha-lipoic acid side effects. Besides a physical exam, which may include blood tests, diagnosis usually requires: 1. Its other name is thioctic acid, which was obtained in 1950 from a bovine liver. Side effects of alpha lipoic acid supplements Alpha lipoic acid (ALA), or 1, 2-dithiolane-3-pentanoic acid, plays a significant role in metabolism of mitochondrial energy. In a few small studies, people who had diabetic neuropathy experienced less pain, improved performance on nerve function tests, and improvements in other signs and symptoms. Side effects: Side effects are rare and toxicity risk is very low. . Accessed April 7, 2020. Check with your doctor before starting a new physical activity, especially if you're taking medications that lower your blood sugar. Alpha lipoic acid is generally a safe supplement to take however there are few potential dangers a user should be made aware of. Source: Alpha Lipoic Acid: Top 10 Benefits & Possible Side Effects by Dr. Edward Group Antioxidants are nutrients that counteract the natural deterioration of cells. People who don't get enough vitamin B-12 may have a higher risk of neuropathy and other nervous system (neurological) problems. And Like drug side effect commercials, “ may cause diarrhea or constipation, sleepiness or sleeplessness. Alpha Lipoic Acid Side Effects. Alpha-lipoic acid is a natural protective antioxidant. Serum folate, vitamin B12 levels and diabetic peripheral neuropathy in type 2 diabetes: A meta-analysis. … Although beneficial for the health, it may have some side effects. Some of these studies also suggested that the treatment effect is greater when started early in the disease's course. Like alpha lipoic acid-my research led me to only take the R component. This article provides information regarding the same. ... Side effects may include nausea, vomiting or agitation. Advertising revenue supports our not-for-profit mission. Alpha-lipoic acid is produced in small amounts in the mitochondria, which, you may remember from science class, is the “powerhouse” of a cell. Certain drugs may lead to a B-12 deficiency, including: It's unclear whether taking vitamin B-12 supplements can help treat diabetic neuropathy. Although not all side effects are known, alpha-lipoic acid is thought to be possibly safe when taken as directed. Some may interfere with certain diabetes medications, and some can increase the risk of kidney problems. Alpha-lipoic acid is a vitamin-like chemical called an antioxidant.Yeast, liver, kidney, spinach, broccoli, and potatoes are good sources of alpha-lipoic acid.It is also made in the laboratory for use as medicine. Joint pain: Rheumatoid arthritis or parvovirus? We comply with the HONcode standard for trustworthy health information -. Call your doctor or get medical Side effects of ALA supplementation are generally mild and include a skin rash. Accessed April 7, 2020. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Accessed April 7, 2020. ALA might cause blood sugar levels to drop, so people with diabetes should consult with their health-care providers before taking it. Alpha-lipoic acid (ALA) is a possible alternative remedy for pain from neuropathy due to diabetes. Although research into the relationship between dietary supplements and diabetic neuropathy is ongoing, eating a healthy diet is widely recognized as a key part of managing your blood sugar and diabetes complications such as diabetic neuropathy. Your blood sugar under control may help with symptoms of diabetes including burning, pain, and in... Is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment is! With diabetes should consult with their health-care providers before taking it diabetes and nerve-related of... Effects of alpha lipoic acid alpha-lipoic acid not be consumed by pregnant.. Oxidative stress is a natural compound with antioxidant properties and other nervous System ( neurological ) problems you report. Effect is greater when started early in the disease 's course kidneys liver! 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